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我组陆益梅等同学在Biomaterials上发表论文

发布日期:2013-03-06

题目: In vivo behavior of near infrared-emitting quantum dots

作者: Yimei Lu(a), Yuanyuan Su(a)*, Yanfeng Zhou(a), Jie Wang(a), Fei Peng(a), Yiling Zhong(a), Qing Huang(b), Chunhai Fan(b), and Yao He(a)*

单位:
a Institute of Functional Nano and Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China
b Laboratory of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China

摘要: Near-infrared (NIR, 700-900 nm) fluorescent nanomaterials-based probes have shown major impacts on high-resolution and high-sensitivity bioimaging applications. Typically, NIR-emitting quantum dots (QDs) are highly promising as NIR bioprobes due to their unique optical properties. However, NIR-emitting QDs-related in vivo behavior remains unknown at present, severely limiting their wide-ranging bioapplications. Herein, we investigate short- and long-term in vivo biodistribution, pharmacokinetics, and toxicity of the NIR-emitting QDs. Particularly, we reveal that the NIR-emitting QDs are initially accumulated in liver, spleen, and lung for short-time (0.5-4 h) post-injection, and then increasingly absorbed by kidney during long-time (4-94 days) blood circulation. Obviously time-dependent biodistribution is observed: with time continues, most of NIR-emitting QDs are finally accumulated in liver and kidney; comparatively, less NIR-emitting QDs are observed in spleen, lung, and bone marrow. Furthermore, histological and biochemical analyses, and body weight measurements demonstrate that there is no overt toxicity of NIR-emitting QDs in mice even at long-time (94 days) exposure time.

影响因子: 7.404

分区情况: 1区

 

 
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