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课题组彭飞等同学在Biomaterials上发表论文

发布日期:2014-03-25


题目: Doxorubicin-loaded silicon nanowires for the treatment of drug-resistant cancer cells


作者:Fei Peng, Yuanyuan Su*, Xiaoyuan Ji, Yiling Zhong, Xinpan Wei, Yao He*



单位:
Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China


摘要:Multidrug resistance (MDR) remains a major challenge for cancer treatment thus far. Free doxorubicin (DOX, one of the most widely used chemotherapy agents for cancer treatment) generally features a large value of resistant factor (RF), which is regarded as a significant parameter to assess therapeutic efficiency of cross-resistance. To address this issue, we herein present a kind of silicon nanowires (SiNWs)-based drug nanocarriers (SiNW-DOX), which is high-efficacy for treatment of drug-resistant cancer cells. Typically, drug-resistance cancer cells (e.g., MCF-7/ADR cells) can be significantly inhibited by the SiNWs-based nanocarriers, exhibiting ~10% cell viability during 72-h incubation with the SiNWs-DOX (80 μg mL-1 DOX), which is in sharp contrast to free DOX-treated cells preserving ~40% cell viability. Remarkably, the RF value of SiNW-DOX is as low as ~2.0, which is much better than that (~300) of free DOX under the same experiment conditions. To the best of our knowledge, it is the lowest RF value ever reported by nanomaterials-based drug carriers (3.3-24.7).



影响因子: 7.604


分区情况: 1区

DOI: 10.1016/j.biomaterials.2014.03.032

 
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