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课题组苏邵博士后等在Nano Today上发表论文

发布日期:2011-03-15

题目:Silicon Nanowires-Based Highly-Efficient SERS-Active Platform for Ultrasensitive DNA Detection

作者:Yao He*, Shao Su, Tingting Xu, Yiling Zhong, J. Antonio Zapien, Jiang Li, Chunhai Fan*, Shuit-Tong Lee*

第一单位:Institute of Functional Nano and Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices, Soochow University, Suzhou, Jiangsu 215123, China

摘要:A nanostructured complex, silicon nanowires (SiNWs) coated with in-situ grown AgNPs (SiNWs@AgNPs), is developed as a well-defined surface-enhanced Raman Scattering (SERS)-active platform for ultrasensitive DNA detection. Such SiNWs@AgNPs nanostructure possesses an extremely high SERS enhancement factor. We design a DNA sensor based on the nanostructure via immobilization of capture probe DNA at the surface of AgNPs, and a sandwich strategy for the detection of target DNA that brings a reporter probe labeled with a dye to the proximity of the surface, leading to high SERS signals. This silicon nanostructure-based biosensor platform can detect a remarkably low DNA concentration at 1-10 fM, which is comparable to the lowest DNA concentration ever detected via SERS. We expect this highly sensitive and robust SiNWs-based SERS platform may serve as a practical and powerful tool for biomolecular sensing and biomedical analysis.

影响因子: 13.237

分区情况: 1区

链接:http://funsom.suda.edu.cn/index.aspx?menuid=3&type=articleinfo&lanmuid=47&infoid=374&language=cn

 
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