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课题组宋斌等与医学部何苏丹老师课题组合作在 Biomaterials 上发表论文

发布日期:2016-08-30


题目: Aqueous synthesized quantum dots interfere with the NF-kB pathway and confer anti-tumor, anti-viral and anti-inflammatory effects


作者:Zhilin Hu, Bin Song(共同第一作者), Lei Xu, Yiling Zhong, Fei Peng, Xiaoyuan Ji, Fang Zhu, Chengkui Yang, Jinying Zhou, Yuanyuan Su, Suning Chen, Yao He*, Sudan He*


单位:
1.Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou 215123, China.

2.Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China.

3.Jiangsu Institute of Hematology (JIH), Key Laboratory of Thrombosis and Hemostasis of Ministry of Health, the First Affiliated Hospital of Soochow University, Suzhou 215006, China.

4.Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China. Electronic address: yaohe@suda.edu.cn.

5.Cyrus Tang Hematology Center and Collaborative Innovation Center of Hematology, Jiangsu Institute of Hematology, the First Affiliated Hospital, and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou 215123, China. Electronic address: hesudan@suda.edu.cn.


摘要:The NF-κB pathway plays crucial roles in inflammatory responses and cell survival. Aberrant constitutive NF-κB activation is associated with various human diseases including cancer and inflammatory and auto-immune diseases. Consequently, it is highly desirable to develop new kinds of inhibitors, which are highly efficacious for blocking the NF-κB pathway. In this study, by using a typical kind of aqueous synthesized quantum dots (QDs), i.e., CdTe QDs, as a model, we for the first time demonstrated that the QDs could selectively affect the cellular nuclear factor-κB (NF-κB) signaling pathway, but do not affect the AKT or ERK pathways. Typically, the QDs efficiently inhibited the activation of IKKα and IKKβ, resulting in the suppression of both the canonical and the non-canonical NF-κB signaling pathways. Inhibition of NF-κB by QDs downregulates anti-apoptotic genes and promotes apoptosis in cancer cells. The QDs induced NF-κB inhibition and cytotoxicity could be blocked by N-acetylcysteine due to the reduced cellular uptake of QDs. Importantly, inhibition of NF-κB by QDs displayed promising effects against the viral replication and in vivo bacterial endotoxin-induced inflammatory responses. These data suggest the QDs as potent inhibitors of the NF-κB signaling pathway, both in vitro and in vivo. Our findings highlight the potential of using QDs in the development of anti-cancer, anti-viral, and anti-inflammatory approaches, and also facilitate better understanding of QDs-related cellular behavior under the molecular level.

影响因子:8.387


分区情况:2区

链接http://ac.els-cdn.com/S0142961216304586/1-s2.0-S0142961216304586-main.pdf?_tid=c6b31766-cb22-11e6-b8a1-00000aacb35e&acdnat=1482726270_b17f33fd8ec7c3a62c957d4bc162d040

 
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