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我组魏新盼等同学在Small上发表论文

发布日期:2013-03-06

题目: A Molecular Beacon-Based Signal-Off Surface-Enhanced Raman Scattering Strategy for Highly Sensitive, Reproducible, and Multiplexed DNA Detection

作者: Xinpan Wei, Shao Su, Yuanyuan Guo, Xiangxu Jiang, Yiling Zhong, Yuanyuan Su, Chunhai Fan, Shuit-Tong Lee, and Yao He*

单位: Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, PR China.


摘要:
Stem-loop oligonucleotides tagged with organic dyes are employed as capture and reporter probes in a molecular beacon-based signal-off surface- enhanced Raman scattering (SERS) strategy. DNA strands are immobilized on a gold nanoparticle-decorated silicon nanowire array (AuNPs@SiNWAr). DNA with a concentration down to ≈10 fM is detected under irradiation from a low-power laser, which is better than or comparable to that detected by signal-on SERS methods. The signal-off strategy allows identification of single-base mismatches and detection of multiplexed DNA.

影响因子: 8.349

分区情况:
1区

链接: http://dx.doi.org/10.1002/smll.201202914

 
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