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课题组周炎烽等同学在Biomaterials上发表论文

发布日期:2015-09-07

题目: A real-time documentation and mechanistic investigation of quantum dots-induced autophagy in live Caenorhabditis elegans

作者: Yanfeng Zhou, Qin Wang(共同第一作者), Bin Song, Sicong Wu, Yuanyuan Su, Huimin Zhang*, Yao He*

单位:Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou 215123, China.

Institutes of Biology and Medical Sciences (IBMS), Soochow University, Suzhou 215123, China

摘要: Autophagy is a highly important intracellular process for the degradation of endogenous or foreign contents in the cytoplasm. Though nanomaterials-induced autophagy has been extensively studied, realtime information about the autophagic process induced by nanomaterials in live organisms remains unknown. Here by using Caenorhabditis elegans as the model organism and fluorescent semiconductor quantum dots (QDs) as a representative nanomaterial, we systematically investigated the phenomenon of QDs-induced autophagy in live organisms. Our results demonstrated that the internalized QDs trigger a complete autophagic process in C. elegans intestinal cells. Further investigations revealed that this QDinduced autophagy in C. elegans is neither a response to released heavy metal ions by the QDs, nor an attempt to engulf exogenous QD materials, but a defensive strategy of the organism to clear and recycle damaged endosomes. Of particular significance, for the first time, we presented real-time tracking of autophagosomes formation in live organisms, providing detailed temporal-spatial information of this process. This study may help us better understand the relationship between nanomaterials and autophagy in vivo, and provide invaluable information for safety evaluation and bio-application of nanomaterials.

影响因子:8.557


分区情况: 1区

链接:http://www.sciencedirect.com/science/article/pii/S0142961215007188

 
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