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Paper published in Nano Research by Airui Jiang et.al.

Date released: 2017-09-11

Title:Doxorubicin-loaded silicon nanoparticles impregnated into red blood cells featuring bright fluorescence, strong photostability, and lengthened blood residency

Authors:Airui Jiang, Bin Song(Co-first author), Xiaoyuan Ji, Fei Peng, Houyu Wang, Yuanyuan Su and Yao He

Institute of Functional Nano & Soft Materials (FUNSOM) and Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, China

Abstract:Taking unique advantages of fluorescent silicon nanoparticles (SiNPs), long circulation red blood cells (RBCs), and anti-cancer drug molecules (i.e., Doxorubicin (DOX)), we present a kind of multifunctional DOX loaded SiNPs impregnated into RBCs. Of particular significance, the resultant drug delivery systems (DDSs) simultaneously exhibit bright fluorescence coupled with robust photostability (i.e., ∼24% loss of fluorescent intensity after 25 min continuous laser irradiation), and significantly lengthened blood residency (i.e., t1/2 = 7.31±0.96 h, 3.9 times longer than pure DOX-loaded SiNPs). Therefore, we envision this novel DDS featuring multi-functionalities would show high promise for cancer diagnosis and therapy, particularly for tumor imaging and chemotherapy in synchronous manners.



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