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Paper published in Analytical Chemistry by Xiangxu Jiang et al.

Date released: 2013-03-06

Title: Surface-Enhanced Raman Scattering-Based Sensing In Vitro: Facile and Label-Free Detection of Apoptotic Cells at the Single-Cell Level

Authors: Xiangxu Jiang, Ziyun Jiang, Tingting Xu, Shao Su, Yiling Zhong, Fei Peng, Yuanyuan Su, and Yao He*

Departments: Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou 215123, China

Abstract: Surface-enhanced Raman scattering (SERS) is well recognized as a powerful analytical tool, enabling ultrahigh sensitive detection of analytes at low concentrations, even down to single-molecule level. Of particular note, in comparison to sufficient investigations on SERS-based detection of biomolecules (e.g., DNA and protein), there has been relatively scanty information regarding in vitro and in vivo detection. In this Article, we demonstrate a kind of SERS-active substrate, i.e., AgNPs-decorated silicon wafer (AgNPs@Si), as a high-performance in vitro sensing platform for single-cell detection of apoptotic cells. The AgNPs@Si yields highly reproducible SERS signals with an enhancement factor of 107. Remarkably, cellular experiments show that facile, noninvasive, label-free, and sensitive detection of apoptotic cells is readily realized using the high-performance SERS-active platform. Three kinds of apoptotic cells treated with apoptosis inducer are facilely and sensitively detected at the single-cell level, suggesting the exciting potential of AgNPs@Si for SERS-based in vitro analysis and detection.

IF: 5.856

Links: http://pubs.acs.org/doi/abs/10.1021/ac303337b

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