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Paper published in Nanoscale by Yu Shi, Na Chen et. al.

Date released: 2018-01-24

Title:Silicon nanohybrids-based SERS chip armed with an internal standard for broad-range, sensitive and reproducible simultaneous quantification of lead (II) and mercury (II) in real systems

Authors:Yu Shi, Na Chen (co-first author), Yuanyuan Su, Houyu Wang* and Yao He*

Laboratory of Nanoscale Biochemical Analysis, Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano & Soft Materials (FUNSOM), and Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, Jiangsu 215123, China.

Abstract:Lead ions (Pb2+) and mercury ions (Hg2+), as the two common coexisting heavy metal ions, bring severe risks to environment and human health. Up to date, there is yet no surface-enhanced Raman scattering (SERS) sensor for simultaneous quantification of Pb2+ and Hg2+ in real systems. Herein, the first demonstration of SERS chips for simultaneously quantifying Pb2+ and Hg2+ in real systems is presented based on the combination of reproducible silicon nanohybrids substrates and corrective internal standard (IS) sensing strategy. Such chip is made of silver nanoparticles decorated silicon wafer, with modification of IS molecules of 4-Aminothiophenol. The as-prepared chip is further functionalized with Pb2+- and Hg2+- specific DNA strands, capable of simultaneous detection Pb2+ and Hg2+. Quantitatively, with the correction by IS Raman signals, the broad dynamic ranges of 100 pM to 10 μM for Pb2+, and 1 nM to 10 μM for Hg2+ are achieved, with the detection limit down to 19.8 ppt for Pb2+ and 168 ppt for Hg2+, respectively. For real applications, we further demonstrate that Pb2+ and Hg2+ spiked into industry waste water can be readily distinguished via the presented chip, with the relative standard deviation (RSD) value less than ~15%. More significantly, such resultant SERS chip can be well coupled with a hand-held Raman instrument, ready for qualitative analysis of both Pb2+ and Hg2+ from real systems in portable manners. Our results suggest this high-quality SERS chip as a powerful tool for on-site detection of various heavy metal ions in real samples in the field of food safety and environment protection.



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