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Paper published in Nanotechnology by Sicong Wu et. al., cooperating with Prof. Kai Yang's group.

Date released: 2017-03-01

Title:One-pot synthesis of silicon based nanoparticles with incorporated phthalocyanine for long-term bioimaging and photo-dynamic therapy of tumors

Authors:Liu, Jiaojiao; Wang, Rui; Wu, Sicong; Yuan, Bing; Bao, Meimei; Li, Jingliang; Dou, Yujiang; He, Yao*; Yang, Kai*

1. Coll Phys Optoelect & Energy, Ctr Soft Condensed Matter Phys & Interdisciplinar,Soochow University, Suzhou 215123, China

2. Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-based Functional Materials & Devices, Soochow University, Suzhou 215123, China

Abstract:Combining the merits of delivery vectors with drug molecules is one of the key directions for development of efficient cancer monitoring and treatment techniques. In this work, a novel type of silicon based composite nanoparticles (NPs) with incorporated hydrophobic phthalocyanine molecules (Pc) was synthesized via a facile one-pot method. The as-synthesized Pc@Si NPs, with a small size of 4.2 ± 0.8 nm, have excellent dispersibility in water and good biocompatibility with cells, in addition to favorable photoluminescence and robust photostability even in cells. Moreover, the Pc@Si NPs show significant in vitro cancer cell killing and in vivo tumor inhibiting abilities upon near-infrared light exposure, due to the photodynamic therapy (PDT) effect of Pc. This work develops an efficient fluorescent PDT drug carrier; moreover, the facile one-pot synthesis strategy may be used generally to prepare silicon-based composite NPs incorporated with diverse hydrophobic drugs/diagnostic molecules for a wide range of biomedical applications.



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