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>Paper published in Scientific Reports by Yanfeng Zhou et. al., cooperating with Dr. Xu Shiqing's group

Date released: 2016-01-25


Title:Targeting and retention enhancement of quantum dots decorated with amino acids in an invertebrate model organism


Authors:Rui Xing, Xuedong Chen(co-first author), Yanfeng Zhou(co-first author), Jue Zhang, Yuanyuan Su, Jianfeng Qiu, Yanghu Sima, Keqin Zhang*,Yao He*, Shiqing Zhang*


Departments:
1.School of Biology and Basic Medical Sciences, Medical College, Soochow University, Suzhou 215123, China.

2.National Engineering Laboratory for Modern Silk (NESER), Soochow University, Suzhou 215123, China.

3.Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China.



Abstract:The use of quantum dots (QDs) in biological imaging applications and targeted drug delivery is expected to increase. However, the efficiency of QDs in drug targeting needs to be improved. Here, we show that amino acids linked to CdTe QDs significantly increased the targeted transfer efficiency and biological safety in the invertebrate model Bombyx mori. Compared with bare QDs530, the transfer efficiency of Ala- and Gly-conjugated QDs (QDs530-Ala and QDs530-Gly) in circulatory system increased by 2.6±0.3 and 1.5±0.3 times, and increased by 7.8±0.9 and 2.9±0.2 times in target tissue silk glands, respectively, after 24h of QDs exposure. Meanwhile, the amount of conjugated QDs decreased by (68.4±4.4)% and (46.7±9.1)% in the non-target tissue fat body, and the speed at which they entered non-target circulating blood cells significantly decreased. The resultant QDs530-Ala revealed a better structural integrity in tissues and a longer retention time in hemolymph than that of QDs530 after exposure via the dorsal vessel. On the other hand, QDs530-Ala significantly reduced the toxicity to hemocytes, silk gland, and fat body, and reduced the amount of reactive oxygen species (ROS) in tissues.


IF:5.228

Link:http://sci-hub.cc/10.1038/srep19802

 
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